Robert Rosen (June 27, 1934 – December 28, 1998), sometimes called “Biology’s Newton”, was a mathematical biologist who fathered one of explanations to the question about what is life. Dr. Rosen dedicated his academic life to biology and pure mathematics, which provided him with the necessary tools to live an extremely productive intellectual life. In his opus magnum “Life Itself: “, Rosen arrives at the unexpected conclusion that no organism can be simulated. This is: organisms are not machines. Robert Rosen’s famous take on life as uncomputable has been studied from different perspectives. In recent years, special interest in his work has regained strength in Computer Science and its Philosophy: if Rosen’s argument holds, then Artificial Life will have a hard time producing life in silico. Based on recent work of Tom Froese (2024), it could be argued that Artificial Minds might be uncomputable as well. To celebrate 90 years of Rosen’s birth, this panel will review the current status of his ideas and his central argument from the perspective of expert researchers in the field of Theoretical Biology, Philosophy of Science, Computing Theory and Cognitive Science.